Nose-to-brain drug delivery by HS15 micelles for brain targeting of insoluble drug

• Main Authors: Wei Zhang (Author), Long Wan (Author), Meiqi Han (Author), Wen Guo (Author), Zhiqi Wang (Author), Xinyue Zhang (Author), Xuyang Liu (Author), Jiahao Wang (Author), Yuling Mao (Author)
• Format: Book
• Published: Compuscript Ltd, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Agomelatine (AGO) is an antidepressant with limited clinical application due to its low bioavailability caused by poor water solubility, severe hepatic degradation, and poor intracerebral distribution. Nanotechnology-based strategies constitute a powerful tool by utilizing drug solubility and target...