Protective role of the curcumin derivative, FM0807, in regulating JAK2/STAT3 and TGF-β1/SMAD2/3 signaling pathways in glomerular mesangial cells and renal function in db/db mice

• Main Authors: Nanwen Zhang (Author), Duoduo Lin (Author), Honglin Wang (Author), Ningning Zheng (Author), Weipeng Lai (Author), Liangyi Li (Author), Jianhua Xu (Author), Xiaole Chen (Author)
• Format: Book
• Published: Compuscript Ltd, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To determine the protective effects of FM0807 against diabetes-induced renal inflammation and fibrosis and the underlying mechanisms in vivo and in vitro. FM0807 was administered to db/db mice. Glomerular mesangial cells (HBZY-1) were cultured under high glucose conditions with or without FM0807. Ge...