Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy

• Κύριοι συγγραφείς: Yanyu Jiang (Συγγραφέας), Shuaishuai Ni (Συγγραφέας), Biying Xiao (Συγγραφέας), Lijun Jia (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2023-11-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Ubiquitin (Ub) and ubiquitin-like (Ubl) pathways are critical post-translational modifications that determine whether functional proteins are degraded or activated/inactivated. To date, >600 associated enzymes have been reported that comprise a hierarchical task network (e.g., E1-E2-E3 cascade en...