Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia

• Main Authors: Carolina Muscoli (Author), Concetta Dagostino (Author), Sara Ilari (Author), Filomena Lauro (Author), Micaela Gliozzi (Author), Erlisa Bardhi (Author), Ernesto Palma (Author), Vincenzo Mollace (Author), Daniela Salvemini (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of the N-methyl-D-aspartate receptor (NMDAR) is fundamental in the development of hyperalgesia. Overactivation of this receptor releases superoxide and nitric oxide that, in turn, forms peroxynitrite (PN). All of these events have been linked to neurotoxicity. The receptors and enzymes in...