Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

• Main Authors: Zhou Guo (Author), Jiamin Lin (Author), Kai Sun (Author), Jiayou Guo (Author), Xudong Yao (Author), Genchun Wang (Author), Liangcai Hou (Author), Jingting Xu (Author), Jiachao Guo (Author), Fengjing Guo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression. Because iron deposition is a major pathological event in ferroptosis, deferoxamine (DFO), an effective ir...