Palmitic acid activates NLRP3 inflammasome and induces placental inflammation during pregnancy in mice

• Main Authors: Michiya SANO (Author), Sayaka SHIMAZAKI (Author), Yasuaki KANEKO (Author), Tadayoshi KARASAWA (Author), Masafumi TAKAHASHI (Author), Akihide OHKUCHI (Author), Hironori TAKAHASHI (Author), Akira KUROSAWA (Author), Yasushi TORII (Author), Hisataka IWATA (Author), Takehito KUWAYAMA (Author), Koumei SHIRASUNA (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Maternal obesity is one of the major risk factors for pregnancy complications and is associated with low-grade chronic systemic inflammation due to higher levels of pro-inflammatory cytokines such as interleukin (IL)-1β. Pregnant women with obesity have abnormal lipid profiles, characterized by high...