Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of <i>Schistosoma mansoni</i> Infection

• Main Authors: Omary Mashiku Minzi (Author), Rajabu Hussein Mnkugwe (Author), Eliford Ngaimisi (Author), Safari Kinung'hi (Author), Anna Hansson (Author), Anton Pohanka (Author), Appolinary Kamuhabwa (Author), Eleni Aklillu (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Praziquantel (PZQ) and dihydroartemisinin-piperaquine (DHP) combination recently showed superior effectiveness than PZQ alone to treat intestinal schistosomiasis. In this follow-up study, we investigated the effect of DHP co-administration on the pharmacokinetics of PZQ and its enantiomers among 64...