Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models

• Main Authors: Jaakko Itkonen (Author), Ada Annala (Author), Shirin Tavakoli (Author), Blanca Arango-Gonzalez (Author), Marius Ueffing (Author), Elisa Toropainen (Author), Marika Ruponen (Author), Marco G. Casteleijn (Author), Arto Urtti (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ciliary neurotrophic factor (CNTF) is one of the most studied neuroprotective agents with acknowledged potential in treating diseases of the posterior eye segment. Although its efficacy and mechanisms of action in the retina have been studied extensively, it is still not comprehensively understood w...