A single exposure to brivaracetam or perampanel does not cause cell death in neonatal rats

• Main Authors: Eric Witherspoon (Author), Nicholas Zuczek (Author), Gabrielle Williams (Author), Briana Bernstein (Author), Anjik Ghosh (Author), Marko Culjat (Author), Suhasini Kaushal (Author), Patrick A. Forcelli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionExposure to a range of anti-seizure medications (ASMs) during early brain development adversely impacts neurodevelopmental outcomes in both animal models and in clinical studies. Many ASMs, including phenobarbital, phenytoin, valproate (VPA), and benzodiazepines, are associated with acut...