Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer

• Main Authors: Yanhong Pan (Author), Qian Zheng (Author), Wenting Ni (Author), Zhonghong Wei (Author), Suyun Yu (Author), Qi Jia (Author), Meng Wang (Author), Aiyun Wang (Author), Wenxing Chen (Author), Yin Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aerobic glycolysis plays a decisive role in cancer growth. However, its role in cancer metastasis was rarely understood. Cantharidin a natural compound from an arthropod insect cantharis exerts potent anticancer activity. Here we found cantharidin possesses significant anti-metastatic activity on br...