Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

• প্রধান লেখক: Jayasree Santhanakrishnan (লেখক), Prabhu Meganathan (লেখক), Hemamalini Vedagiri (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Open Exploration Publishing Inc., 2024-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome. Structure of HER2/ERBB2 protein was obtained from PDB database, and using Schrödinger software protein structure was analysed...