Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

• मुख्य लेखकों: Jayasree Santhanakrishnan (लेखक), Prabhu Meganathan (लेखक), Hemamalini Vedagiri (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Open Exploration Publishing Inc., 2024-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome. Structure of HER2/ERBB2 protein was obtained from PDB database, and using Schrödinger software protein structure was analysed...