Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

• Autori principali: Jayasree Santhanakrishnan (Autore), Prabhu Meganathan (Autore), Hemamalini Vedagiri (Autore)
• Natura: Libro
• Pubblicazione: Open Exploration Publishing Inc., 2024-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome. Structure of HER2/ERBB2 protein was obtained from PDB database, and using Schrödinger software protein structure was analysed...