Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response

• Main Authors: Xuesong Li (Author), Xiang Chen (Author), Longbin Zheng (Author), Minghong Chen (Author), Yunjia Zhang (Author), Ruigong Zhu (Author), Jiajing Chen (Author), Jiaming Gu (Author), Quanwen Yin (Author), Hong Jiang (Author), Xuan Wu (Author), Xian Ji (Author), Xin Tang (Author), Mengdie Dong (Author), Qingguo Li (Author), Yuanqing Gao (Author), Hongshan Chen (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis, while the underlying mechanism remains elusive. Here, we report that the non-canonical stimulator of interferon genes (STING)-PKR-like ER kinase (PERK) pathway was significantly activated in both human and...