Drug-drug interactions of tacrolimus
Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions. Pharmacokinetic interactions between tacrolimus and other drugs: Concer...
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| Main Authors: | , , , , |
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| Format: | Book |
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Srpsko lekarsko drustvo,
2015-01-01T00:00:00Z.
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| Summary: | Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions. Pharmacokinetic interactions between tacrolimus and other drugs: Concerning the fact that it is also a medicine with the narrow therapeutic range, its interactions with other drugs mediated by both P-glycoprotein and CYP3A enzymes are potentially very important. Conclusion: Interactions between tacrolimus and other drugs leading to overexposure to tacrolimus is connected with significant toxicity, while the subtherapeutic blood concentrations increase the probability of transplanted organ rejection. |
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| Item Description: | 2334-9492 2334-9492 10.5937/hpimj1503291R |