Inhibition of Sphingosine Kinase 1 Reduces Sphingosine-1-Phosphate and Exacerbates Amyloid-Beta-Induced Neuronal Cell Death in Mixed-Glial-Cell Culture

• Hoofdauteurs: Tomoki Minamihata (Auteur), Katsura Takano-Kawabe (Auteur), Mitsuaki Moriyama (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2024-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In Alzheimer's disease (AD) pathology, the accumulation of amyloid-beta (Aβ), a main component of senile plaques, activates glial cells and causes neuroinflammation. Excessive neuroinflammation results in neuronal dropouts and finally produces the symptoms of AD. Recent studies suggest that dis...