Inhibition of Sphingosine Kinase 1 Reduces Sphingosine-1-Phosphate and Exacerbates Amyloid-Beta-Induced Neuronal Cell Death in Mixed-Glial-Cell Culture

• Váldodahkkit: Tomoki Minamihata (Dahkki), Katsura Takano-Kawabe (Dahkki), Mitsuaki Moriyama (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2024-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

In Alzheimer's disease (AD) pathology, the accumulation of amyloid-beta (Aβ), a main component of senile plaques, activates glial cells and causes neuroinflammation. Excessive neuroinflammation results in neuronal dropouts and finally produces the symptoms of AD. Recent studies suggest that dis...