Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice

• Main Authors: Yifan Lu (Author), Lu Jiang (Author), Wanlu Li (Author), Meijie Qu (Author), Yaying Song (Author), Xiaosong He (Author), Zhijun Zhang (Author), Guo-Yuan Yang (Author), Yongting Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neural stem cell (NSC) transplantation is a promising treatment to improve the recovery after brain ischemia. However, how the survival, proliferation, migration, and differentiation of implanted NSC are influenced by endogenous neuronal activity remains unclear. In this work, we used optogenetic te...