Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

• मुख्य लेखकों: Bhagirath Chaurasia (लेखक), Li Ying (लेखक), Chad Lamar Talbot (लेखक), John Alan Maschek (लेखक), James Cox (लेखक), Edward H. Schuchman (लेखक), Yoshio Hirabayashi (लेखक), William L. Holland (लेखक), Scott A. Summers (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or n...