Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

• Main Authors: Bhagirath Chaurasia (Author), Li Ying (Author), Chad Lamar Talbot (Author), John Alan Maschek (Author), James Cox (Author), Edward H. Schuchman (Author), Yoshio Hirabayashi (Author), William L. Holland (Author), Scott A. Summers (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or n...