Aberrant GATA2 Activation in Pediatric B-Cell Acute Lymphoblastic Leukemia

• Main Authors: Han Wang (Author), Bowen Cui (Author), Huiying Sun (Author), Fang Zhang (Author), Jianan Rao (Author), Ronghua Wang (Author), Shuang Zhao (Author), Shuhong Shen (Author), Yu Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GATA2 is a transcription factor that is critical for the generation and survival of hematopoietic stem cells (HSCs). It also plays an important role in the regulation of myeloid differentiation. Accordingly, GATA2 expression is restricted to HSCs and hematopoietic progenitors as well as early erythr...