A piRNA-like Small RNA Induces Chemoresistance to Cisplatin-Based Therapy by Inhibiting Apoptosis in Lung Squamous Cell Carcinoma

• Main Authors: Yuyan Wang (Author), Tyler Gable (Author), Mark Z. Ma (Author), David Clark (Author), Jun Zhao (Author), Yi Zhang (Author), Wei Liu (Author), Li Mao (Author), Yuping Mei (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lung cancer is the leading cause of cancer-related death worldwide. Although advanced drugs have benefitted patients, therapeutic success has largely been hampered because of rapid development of resistance. Here we report that PIWI-interacting RNA likes (piR-Ls), a novel type of functional sncRNAs,...