Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model

• Main Authors: Mohamed Tail (Author), Hao Zhang (Author), Guoli Zheng (Author), Anna-Kathrin Harms (Author), Maryam Hatami (Author), Thomas Skutella (Author), Karl Kiening (Author), Andreas Unterberg (Author), Klaus Zweckberger (Author), Alexander Younsi (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sonic Hedgehog (Shh), extensively researched for its role in early neurogenesis and brain development, has recently been recognized for its neuroprotective potential following neuronal injuries. This study examines the immediate impact of early administered Shh on the local infla...