Prediction of Drug-Drug-Gene Interaction Scenarios of (<i>E</i>)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling

Prediction of Drug-Drug-Gene Interaction Scenarios of (<i>E</i>)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling

Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. However, since (<i>E</i>)-clomiphene ((<i>E</i>)-Clom) and its metabolites are eliminated primarily via Cytochrome P450 (CYP) 2D6 and CYP3A4, exp...

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Main Authors: Christina Kovar (Author), Lukas Kovar (Author), Simeon Rüdesheim (Author), Dominik Selzer (Author), Boian Ganchev (Author), Patrick Kröner (Author), Svitlana Igel (Author), Reinhold Kerb (Author), Elke Schaeffeler (Author), Thomas E. Mürdter (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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