Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo

• Main Authors: Shushan Ge (Author), Haiqing Zhong (Author), Xuewei Ma (Author), Yingbo Zheng (Author), Yi Zou (Author), Fang Wang (Author), Yan Wang (Author), Yue Hu (Author), Yuezhen Li (Author), Wen Liu (Author), Wenjie Guo (Author), Qiang Xu (Author), Yisheng Lai (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the HeLa cell-based IDO1/kynurenine assay, leading to...