Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo

Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the HeLa cell-based IDO1/kynurenine assay, leading to...

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主要な著者: Shushan Ge (著者), Haiqing Zhong (著者), Xuewei Ma (著者), Yingbo Zheng (著者), Yi Zou (著者), Fang Wang (著者), Yan Wang (著者), Yue Hu (著者), Yuezhen Li (著者), Wen Liu (著者), Wenjie Guo (著者), Qiang Xu (著者), Yisheng Lai (著者)
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出版事項: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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