Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo
Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the HeLa cell-based IDO1/kynurenine assay, leading to...
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Taylor & Francis Group,
2020-01-01T00:00:00Z.
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