Differential sensitivity to hypoxia enables shape‐based classification of sickle cell disease and trait blood samples at point of care

• Main Authors: Claudy D'Costa (Author), Oshin Sharma (Author), Riddha Manna (Author), Minakshi Singh (Author), Samrat Singh (Author), Srushti Singh (Author), Anish Mahto (Author), Pratiksha Govil (Author), Sampath Satti (Author), Ninad Mehendale (Author), Yazdi Italia (Author), Debjani Paul (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Red blood cells (RBCs) become sickle‐shaped and stiff under hypoxia as a consequence of hemoglobin (Hb) polymerization in sickle cell anemia. Distinguishing between sickle cell disease and trait is crucial during the diagnosis of sickle cell disease. While genetic analysis or high‐performan...