Elamipretide(SS-31) Attenuates Idiopathic Pulmonary Fibrosis by Inhibiting the Nrf2-Dependent NLRP3 Inflammasome in Macrophages

• Główni autorzy: Yunjuan Nie (Autor), Jiao Li (Autor), Xiaorun Zhai (Autor), Zhixu Wang (Autor), Junpeng Wang (Autor), Yaxian Wu (Autor), Peng Zhao (Autor), Gen Yan (Autor)
• Format: Książka
• Wydane: MDPI AG, 2023-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disease with a limited therapeutic strategy. Mitochondrial oxidative stress in macrophages is directly linked to IPF. Elamipretide(SS-31) is a mitochondrion-targeted peptide that has been shown to be safe and beneficial for multiple dis...