Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes

• Main Authors: Lihong Wang (Author), Zhoujunhao Zhou (Author), Xinming Xu (Author), Yue Li (Author), Rui Zhang (Author), Zhiyan Yu (Author), Xinmei Huang (Author), Shufei Zang (Author), Tiange Sun (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chronic inflammation plays a vital role in the development of gestational diabetes mellitus (GDM). Studies in mouse models show that neutrophil serine proteases (NSPs), neutrophil elastase (NE) and proteinase-3 (PR3) are important drivers of chronic inflammation with consequent m...