Design, Characterization and Pharmacokinetic-Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of Nebivolol for Treatment of Open-Angle Glaucoma

• Hoofdauteurs: Pradeep Singh Rawat (Auteur), Punna Rao Ravi (Auteur), Shahid Iqbal Mir (Auteur), Mohammed Shareef Khan (Auteur), Himanshu Kathuria (Auteur), Prasanna Katnapally (Auteur), Upendra Bhatnagar (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-01-01T00:00:00Z.
• Onderwerpen: article
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This study developed a dual-responsive in situ gel of nebivolol (NEB), a selective β-adrenergic antagonist. The gel could achieve sustained concentrations in the aqueous humor to effectively treat glaucoma. The gel was prepared using a combination of poloxamers (Poloxamer-407 (P407) and Poloxamer-18...