Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

• Main Authors: Adam D. Pfefferle (Author), Yash N. Agrawal (Author), Daniel C. Koboldt (Author), Krishna L. Kanchi (Author), Jason I. Herschkowitz (Author), Elaine R. Mardis (Author), Jeffrey M. Rosen (Author), Charles M. Perou (Author)
• Format: Book
• Published: The Company of Biologists, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted therapies against basal-like breast tumors, which are typically 'triple-negative breast cancers (TNBCs)', remain an important unmet clinical need. Somatic TP53 mutations are the most common genetic event in basal-like breast tumors and TNBC. To identify additional drivers and poss...