Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice

• Main Authors: János Garai (Author), Marcell Krekó (Author), László Őrfi (Author), Péter Balázs Jakus (Author), Zoltán Rumbus (Author), Patrik Kéringer (Author), András Garami (Author), Eszter Vámos (Author), Dominika Kovács (Author), Viola Bagóné Vántus (Author), Balázs Radnai (Author), Tamás Lóránd (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts a unique tautomerase enzymatic activity that has relevance concerning its multiple functions and its small molecule inhibitors have been proven to block its pro-inflammatory effec...