Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice

• Главные авторы: János Garai (Автор), Marcell Krekó (Автор), László Őrfi (Автор), Péter Balázs Jakus (Автор), Zoltán Rumbus (Автор), Patrik Kéringer (Автор), András Garami (Автор), Eszter Vámos (Автор), Dominika Kovács (Автор), Viola Bagóné Vántus (Автор), Balázs Radnai (Автор), Tamás Lóránd (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts a unique tautomerase enzymatic activity that has relevance concerning its multiple functions and its small molecule inhibitors have been proven to block its pro-inflammatory effec...