Computational Design and Development of Benzodioxane-Benzamides as Potent Inhibitors of FtsZ by Exploring the Hydrophobic Subpocket

• Main Authors: Valentina Straniero (Author), Victor Sebastián-Pérez (Author), Lorenzo Suigo (Author), William Margolin (Author), Andrea Casiraghi (Author), Martina Hrast (Author), Carlo Zanotto (Author), Irena Zdovc (Author), Antonia Radaelli (Author), Ermanno Valoti (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistant <i>Staphylococcus aureus</i> is a severe threat, responsible for most of the nosocomial infections globally. This resistant strain is associated with a 64% increase in death compared to the antibiotic-susceptible strain. The prokaryotic protein FtsZ and the cell divis...