The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations

• Main Authors: Jorge E. B. da Rocha (Author), Houcemeddine Othman (Author), Gerrit Botha (Author), Laura Cottino (Author), David Twesigomwe (Author), Samah Ahmed (Author), Britt I. Drögemöller (Author), Faisal M. Fadlelmola (Author), Philip Machanick (Author), Mamana Mbiyavanga (Author), Sumir Panji (Author), Galen E. B. Wright (Author), Clement Adebamowo (Author), Mogomotsi Matshaba (Author), Michéle Ramsay (Author), Gustave Simo (Author), Martin C. Simuunza (Author), Caroline T. Tiemessen (Author), Sandra Baldwin (Author), Mathias Chiano (Author), Charles Cox (Author), Annette S. Gross (Author), Pamela Thomas (Author), Francisco-Javier Gamo (Author), Scott Hazelhurst (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Investigating variation in genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic (PGx) relationships. ADME gene variation is relatively well characterized in European and Asian populations, but data from Afri...