Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

• প্রধান লেখক: Diti Desai (লেখক), Malin Åkerfelt (লেখক), Neeraj Prabhakar (লেখক), Mervi Toriseva (লেখক), Tuomas Näreoja (লেখক), Jixi Zhang (লেখক), Matthias Nees (লেখক), Jessica M. Rosenholm (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2018-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Intracellular drug delivery by mesoporous silica nanoparticles (MSNs) carrying hydrophilic and hydrophobic fluorophores as model drug cargo is demonstrated on 2D cellular and 3D tumor organoid level. Two different MSN designs, chosen on the basis of the characteristics of the loaded cargo, were used...