Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression

• Main Authors: Xiangchen Kong (Author), Yifan Tu (Author), Bingfeng Li (Author), Longmei Zhang (Author), Linxian Feng (Author), Lixiang Wang (Author), Lin Zhang (Author), Huarong Zhou (Author), Xianxin Hua (Author), Xiaosong Ma (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear. Farnesoid X receptor (FXR), the nuclear receptor of bile acids (BAs), is implicated in bariatric surgery. Moreo...