The role of the SGK3/TOPK signaling pathway in the transition from acute kidney injury to chronic kidney disease

• Main Authors: Huapan Shu (Author), Yumei Wang (Author), Hui Zhang (Author), Qingqing Dong (Author), Lulu Sun (Author), Yuchi Tu (Author), Qianqian Liao (Author), Li Feng (Author), Lijun Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Profibrotic phenotype of renal tubular epithelial cells (TECs) featured with epithelial to mesenchymal transition (EMT) and profibrotic factors secretion, and aberrant accumulation of CD206+ M2 macrophages are the key points in the transition from acute kidney injury (AKI) to chronic k...