Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABAA receptor gamma2 subunit in the cerebellum

• Main Authors: Elli Leppä (Author), Anni-Maija Tuulikki Linden (Author), M. Isabel Aller (Author), Peer Wulff (Author), Olga Vekovischeva (Author), Bernhard Lüscher (Author), Hartmut Lüddens (Author), William Wisden (Author), Esa R Korpi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the receptor, especially on those that form extrasynaptic...