Pharmacogenomics of Cardiovascular Pharmacology: Molecular Network Analysis in Pleiotropic Effects of Statin - an Experimental Elucidation of the Pharmacologic Action From Protein-Protein Interaction Analysis

• Main Authors: Masayuki Shiota (Author), Hiromi Kusakabe (Author), Yuko Hikita (Author), Takafumi Nakao (Author), Yasukatsu Izumi (Author), Hiroshi Iwao (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The ebb and flow of cellular life depends largely on signaling pathways and networks, which are regulated by specific protein-protein interactions. These interactions often involve assembly of large signaling complexes containing many different protein kinases, protein phosphatases, their substrates...