Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection.

• Главные авторы: Néstor A Guerrero (Автор), Mercedes Camacho (Автор), Luis Vila (Автор), Miguel A Íñiguez (Автор), Carlos Chillón-Marinas (Автор), Henar Cuervo (Автор), Cristina Poveda (Автор), Manuel Fresno (Автор), Núria Gironès (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Предметы: article
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Inflammation plays an important role in the pathophysiology of Chagas disease, caused by Trypanosoma cruzi. Prostanoids are regulators of homeostasis and inflammation and are produced mainly by myeloid cells, being cyclooxygenases, COX-1 and COX-2, the key enzymes in their biosynthesis from arachido...