Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection.

• Main Authors: Néstor A Guerrero (Author), Mercedes Camacho (Author), Luis Vila (Author), Miguel A Íñiguez (Author), Carlos Chillón-Marinas (Author), Henar Cuervo (Author), Cristina Poveda (Author), Manuel Fresno (Author), Núria Gironès (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation plays an important role in the pathophysiology of Chagas disease, caused by Trypanosoma cruzi. Prostanoids are regulators of homeostasis and inflammation and are produced mainly by myeloid cells, being cyclooxygenases, COX-1 and COX-2, the key enzymes in their biosynthesis from arachido...