Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis

• Main Authors: Hung-Ting Liu (Author), Tse-En Wang (Author), Yu-Ting Hsu (Author), Chi-Chung Chou (Author), Kai-Hung Huang (Author), Cheng-Chih Hsu (Author), Hong-Jen Liang (Author), Hui-Wen Chang (Author), Tzong-Huei Lee (Author), Pei-Shiue Tsai (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin is a potent anti-cancer drug, however, its accompanied organ-toxicity hampers its clinical applications. Cisplatin-associated kidney injury is known to result from its accumulation in the renal tubule with excessive generation of reactive oxygen species. In this study, we encapsulated hono...