Decreased Levels of GSH Are Associated with Platinum Resistance in High-Grade Serous Ovarian Cancer

• Main Authors: Daniela Criscuolo (Author), Rosario Avolio (Author), Matteo Parri (Author), Simona Romano (Author), Paola Chiarugi (Author), Danilo Swann Matassa (Author), Franca Esposito (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive OC histotype. Although initially sensitive to standard platinum-based chemotherapy, most HGSOC patients relapse and become chemoresistant. We have previously demonstrated that platinum resistance is driven by a metabolic shif...