Polygenic risk-stratified screening for nasopharyngeal carcinoma in high-risk endemic areas of China: a cost-effectiveness study

• Main Authors: Da-Wei Yang (Author), Jacob A. Miller (Author), Wen-Qiong Xue (Author), Minzhong Tang (Author), Lin Lei (Author), Yuming Zheng (Author), Hua Diao (Author), Tong-Min Wang (Author), Ying Liao (Author), Yan-Xia Wu (Author), Xiao-Hui Zheng (Author), Ting Zhou (Author), Xi-Zhao Li (Author), Pei-Fen Zhang (Author), Xue-Yin Chen (Author), Xia Yu (Author), Fugui Li (Author), Mingfang Ji (Author), Ying Sun (Author), Yong-Qiao He (Author), Wei-Hua Jia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundNasopharyngeal carcinoma (NPC) has an extremely high incidence rate in Southern China, resulting in a severe disease burden for the local population. Current EBV serologic screening is limited by false positives, and there is opportunity to integrate polygenic risk scores for personalized...