Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System

CRISPR-Cas9 and base editors (BEs) systems are poised to become the gene-editing tool of choice in clinical contexts; however, large-fragment deletion was found in Cas9-mediated mutation cells and mice. In this study, by analyzing 16 gene-edited rabbit lines (including 112 rabbits) generated using S...

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Main Authors: Yuning Song (Author), Zhiquan Liu (Author), Yuxin Zhang (Author), Mao Chen (Author), Tingting Sui (Author), Liangxue Lai (Author), Zhanjun Li (Author)
Format: Book
Published: Elsevier, 2020-09-01T00:00:00Z.
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