Drug-Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism

• Main Authors: Nicola Ferri (Author), Sara De Martin (Author), James Stuart (Author), Sergio Traversa (Author), Franco Folli (Author), Marco Pappagallo (Author), Cedric O'Gorman (Author), Clotilde Guidetti (Author), Andrea Mattarei (Author), Charles E. Inturrisi (Author), Paolo L. Manfredi (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background and Objective Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blocker with higher affinity for GluN2D subtypes. Esm...