Orally Administered <i>N</i>-Oleoyl Alanine Blocks Acute Opioid Withdrawal Induced-Conditioned Place Preference and Attenuates Somatic Withdrawal following <i>Chronic</i> Opioid Exposure in Rats

• Main Authors: Samantha M. Ayoub (Author), Erin M. Rock (Author), Cheryl L. Limebeer (Author), Marieka V. DeVuono (Author), Linda A. Parker (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: Intraperitoneal injections of the endogenous <i>N</i>-acyl amino acid <i>N</i>-Oleoyl alanine (OlAla) effectively reduces both the affective and somatic responses produced by opioid withdrawal in preclinical models. To increase the translational appeal of OlAl...