Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae

• Main Authors: Zhe Liu (Author), Alexander P.N.A. De Porto (Author), Regina De Beer (Author), Joris J.T.H. Roelofs (Author), Onno J. De Boer (Author), Sandrine Florquin (Author), Cornelis Van't Veer (Author), Rudi W. Hendriks (Author), Tom Van der Poll (Author), Alex F. De Vos (Author)
• Format: Book
• Published: Karger Publishers, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Humans with dysfunctional Bruton's tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling evidence indicates that Btk is essential for B cell-mediated immunity, whereas its role in myeloid cell-mediated immunity against infections is controversial. In this study, we de...