Oral administration of a synthetic vinyl-ether plasmalogen normalizes open field activity in a mouse model of rhizomelic chondrodysplasia punctata

• Main Authors: Wedad Fallatah (Author), Tara Smith (Author), Wei Cui (Author), Dushmanthi Jayasinghe (Author), Erminia Di Pietro (Author), Shawn A. Ritchie (Author), Nancy Braverman (Author)
• Format: Book
• Published: The Company of Biologists, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder caused by mutations in peroxisomal genes essential for plasmalogen biosynthesis. Plasmalogens are a class of membrane glycerophospholipids containing a vinyl-ether-linked fatty alcohol at the sn-1 position that affect functions i...