Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor

• Main Authors: James Russell (Author), Louise Fanchon (Author), Hanan Alwaseem (Author), Henrik Molina (Author), Isabella O'Donoghue (Author), Amber Bahr (Author), Elisa deStanchina (Author), Nagavarakishore Pillarsetty (Author), John L. Humm (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model. This is in contrast both to 14C‐labeled gemcitabine, and established expectations, as the dense stroma of pancreatic cancer is unders...