Phosphodiesterase 10A Inhibition Modulates the Corticostriatal Activity and L-DOPA-Induced Dyskinesia

Phosphodiesterase 10A Inhibition Modulates the Corticostriatal Activity and L-DOPA-Induced Dyskinesia

The facilitation of corticostriatal transmission is modulated by the pharmacological inhibition of striatal phosphodiesterase 10A (PDE10A). Since L-DOPA-induced dyskinesia is associated with abnormal corticostriatal transmission, we hypothesized that inhibition of PDE10A would modulate L-DOPA-induce...

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Main Authors: Rayanne Poletti Guimarães (Author), Danilo Leandro Ribeiro (Author), Keila Bariotto Dos Santos (Author), Carlos Henrique Zanello Talarico (Author), Lívea Dornela Godoy (Author), Fernando E. Padovan-Neto (Author)
Format: Book
Published: MDPI AG, 2022-07-01T00:00:00Z.
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3rd Floor Main Library

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