Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl

• Main Authors: Santhosh Baby (Author), Ryan Gruber (Author), Joseph Discala (Author), Veljko Puskovic (Author), Nijo Jose (Author), Feixiong Cheng (Author), Michael Jenkins (Author), James Seckler (Author), Stephen Lewis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fentanyl is a high-potency opioid receptor agonist that elicits profound analgesia and suppression of breathing in humans and animals. To date, there is limited evidence as to whether changes in oxidant stress are important factors in any of the actions of acutely administered fentanyl. This study d...