Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-α Transgenic Mice

• Hoofdauteurs: Iwao Seki (Auteur), Miwa Takai-Imamura (Auteur), Tomomi Kohara-Tanaka (Auteur), Satoshi Shirae (Auteur), Minoru Sasano (Auteur), Hiroaki Matsuno (Auteur), Hiroyuki Aono (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2019-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In the present study, we investigated the effects and mechanisms of action of a combined treatment with etanercept, a soluble tumor necrosis factor receptor (p75) Fc fusion protein, and tacrolimus, a calcineurin inhibitor on the progression of arthritis in human tumor necrosis factor-α (TNF-α) trans...