Artemisinic acid attenuates osteoclast formation and titanium particle-induced osteolysis via inhibition of RANKL-induced ROS accumulation and MAPK and NF-κB signaling pathways

• Main Authors: Tian Gao (Author), Chaohong Yu (Author), Xiaofeng Shi (Author), Yuehao Hu (Author), Yongyun Chang (Author), Jingwei Zhang (Author), Yitian Wang (Author), Zanjing Zhai (Author), Xinlin Jia (Author), Yuanqing Mao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Periprosthetic osteolysis (PPO) is the most common cause of joint arthroplasty failure. Its progression involves both biological and mechanical factors. Osteoclastogenesis induced by wear from debris-cell interactions, ultimately leading to excessive bone erosion, is considered the primary cause of...